Susceptibility of cefditoren pivoxil and other nine antimicrobial agents against fastidious bacteria isolated from respiratory tract
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R969.3

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    Abstract:

    ObjectiveTo realize the isolation status of fastidious bacteria causing respiratory tract infection and antimicrobial susceptibility of fastidious bacteria to cefditoren pivoxil as well as the other 9 antimicrobial agents, so as to provide reference for clinical treatment.Methods Fastidious bacteria isolated from sputum of patients with respiratory tract infection during the year of 2005, 2007, 2008, and JanuaryJune in 2010 were collected. Antimicrobial susceptibility of fastidious bacteria were tested with KirbyBauer method recommended by Clinical and Laboratory Standards Institute (CLSI). ResultsA total of 462 isolates were isolated from 438 patients, βlactamaseproducing rate was as follows: Haemophilus influenzae (HI) 23.62% (30/127), Haemophilus parainfluenzae (HP) 2.51%(5/199), Moraxella catarrhalis (MC) 41.58% (42/101), penicillinresistant Streptococcus pneumoniae (SP) isolates was not found. The susceptibility rate (SR) of HI, HP, MC, and SP to cefditoren pivoxil was 96.30%, 94.36%, 100.00%, and 100.00%, respectively;The SR of HI and HP to cefotaxime, cefuroxime, cefaclor and cefazolin was 83.59%-93.33%, SR to amoxicillin/clavulanic acid was 91.67% and 88.21% respectively; SR of MC and SP to amoxicillin / clavulanic acid was 100.00%; SR of HI to clarithromycin was 87.96%,SR of HP, SP and MC to clarithromycin was 34.29%-59.00%; SR of 4 kinds of fastidious bacteria to tetracycline was 22.86%-63.00%; The resistant rate of HI,HP and MC to trimethoprim/sulfamethoxazole was 54.63%-3.33%.ConclusionCefditoren pivoxil has strong activity against fastidious bacteria causing respiratory tract infection; in order to reduce the emergence of drugresistant strain, clinicians should choose antimicrobial agents according to antimicrobial susceptibility test results.

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袁锦屏,杨灵,邱桂霞,等.呼吸道苛养菌对头孢妥仑匹酯等10种抗菌药物的药敏监测[J].中国感染控制杂志英文版,2011,10(4):289-291.
YUAN Jinping, YANG Ling, QIU Guixia, et al. Susceptibility of cefditoren pivoxil and other nine antimicrobial agents against fastidious bacteria isolated from respiratory tract[J]. Chin J Infect Control, 2011,10(4):289-291.

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  • Received:October 29,2010
  • Revised:December 22,2010
  • Adopted:
  • Online: July 30,2011
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