ObjectiveTo analyze the data and related risk factors of occupational exposure to bloodborne pathogens in a hospital in 2010.MethodsAfter encountering occupational exposure to bloodborne pathogens, health care workers (HCWs)  filled out the designed forms, and submitted them to the department of healthcareassociated infection prevention and control.ResultsA total of  227 HCWs encountered  230  occupational exposure in 2010, 193 of whom  reported 196 sharp injuries, and 34 of whom reported 34 of blood/body fluid exposures; occupational exposure distributed in 48 departments, which top 5 as follows: operating room (34 times), orthopedics department (18), liver and blood vessel surgical department (18), nephrology department (11), and anesthesia department(10).Among occupation distribution, doctors and nurses accounted for 85.46%; 63.48% were longterm HCWs in this hospital, and 36.52%  were interns and HCWs for advanced study. 73.57% of persons worked less than 5 years.  Syringe and suture needles were the main devices for stabbing, using and disposal of the needles were the main procedures leading to stabbing; 70.59% of persons didn’t wear  personal protective equipment when they exposed to  blood/ body fluid, 26.53% of the occurrence persons didn’t wear gloves.ConclusionAnalysis of the occurrence of occupational exposure to bloodborne pathogens can help to identify the key departments, the target population and the risk factors, and to take appropriate intervention.