ObjectiveTo investigate risk factors for general surgical site infection (SSI), so as to adopt preventive and control measures to reduce infection rate.MethodsSSI infection in patients with general surgical operation from January to December  2010 were monitored with  prospective investigation method.Results914 patients were monitored, 15 cases of SSI occurred, SSI rate was 1.64%; risk factors  for SSI were patients’ age, as well as types,duration, category and  modes of operation. There was significant difference in SSI rate between 2010 and 2009 (1.64% vs 3.45%［19/550］, χ2=4.98,P=0.03).ConclusionTargeted monitor and management of risk factors  can reduce SSI rate in general surgical operation.