ObjectiveTo investigate the control efficacy of hospitalacquired multidrugresistant organism infections (MDROHAIs) through carrying out bundle measures in a surgical intensive care unit(SICU).MethodsSICU patients with positive cultures of methicillinresistant Staphylococcus aureus(MRSA), vancomycinresistant Enterococcus(VRE), extendedspectrum βlactamase positive Escherichia coli (ESBLE. coli), ESBL positive Klebsiella pneumoniae (ESBLKp), and multidrugresistant Acinetobacter baumannii(MDRAb) between January 1, 2007 and December 31, 2010 were selected for investigation. From July 1, 2008 to December 31, 2010,patients were investigated prospectively and bundle measures (such as hand hygiene, single room isolation, gloves, and isolation gowns) for patients with MDRO infection or colonization were carried out. From January 1, 2007 to June 30, 2008, medical records of patients (without performing bundle measures) with above 5 pathogens were surveyed retrospectively, and efficacy of bundle measures was analyzed.ResultsFrom January 1, 2007 to December 31, 2010, a total of 3 526 patients were admitted to this SICU, there were 11 207 bed days, and there were totally 104 episodes of MDRO infections including 65(62.50%) cases of ICUassociated infections (ICUAI) and 39(37.50%) nonICUassociated infections. ICUAI,especially MRSA and MDRAb infection, decreased significantly（18.75%）along with the carrying out of bundle measures.ConclusionMDRO infections in SICU are serious, which can be controlled effectively through bundle measures.