ObjectiveTo evaluate the prognostic value of bundle treatment on prognosis of encephalopathy patients with ventilatorassociated pneumonia（VAP）.MethodsSeventytwo mechanically ventilated patients admitted to an intensive care unit (ICU) from September 2010 to March 2012 were randomly divided into experimental and control group, 37 patients in experimental group adopted bundle treatment, 35 patients in control group received conventional treatment, the length of ICU stay, hospital cost and 28day mortality following admission of two groups were compared.ResultsLength of ICU stay in experimental group was significantly shorter than that of control group (［11.93±6.25］ vs ［18.08±7.53］ days, t=3.27， P=0.00); hospitalization cost in experimental group was significantly less than that of control group (［68.7±32.5］ vs ［95.8±38.2］ thousand yuan， t=2.81， P=0.01); 28day mortality following admission in experimental group and control group was 24.32% (9/37) and 31.43% (11/35) respectively, there was no significant difference (χ2=0.22， P＞0.05).ConclusionThe bundle treatment can reduce length of hospital stay and hospital cost of encephalopathy patients with VAP, but can not reduce mortality.