ObjectiveTo evaluate clinical diagnosis and treatment of cirrhosis with spontaneous bacterial peritonitis (SBP).MethodsClinical data of 76 cases of cirrhosis with SBP in hospitalized patients between February 2007 and January 2010 were analyzed retrospectively.Results Of 76 patients, 67.11% (51 cases) had temperature >37℃, 43.42% (33 cases) had no abdominal pain, rebound tenderness and tenderness. Routine examination on abdominal cavity fluid showed that white blood cell count of 38.16%patients (29 cases) were >0.3×109/L,polymorphonuclear leukocyte of 55.26% (42 cases) patients were >25%， 21.05% (16 cases) had positive blood culture, 25.00% (19 cases) had positive culture of abdominal cavity fluid. After patients received general treatment, such as liver protection, diuresis,supportive treatment and rational antimicrobial use, the total cure and improvement rate reached up to 76.32%(58 cases).Conclusion Clinical manifestations of cirrhosis with SBP is atypical, positive rate for bacterial culture is low, early abdominal cavity fluid examination and dynamic observation on peripheral white blood cell count is significant for the diagnosis. The key to the ideal curative effect on SBP is active diagnosis and treatment.