ObjectiveTo design a webbased realtime automatic information system platform for the purpose of healthcareassociated infection(HAI) case surveillance and targeted surveillance. MethodsSystem requirement analysis was adopted to compare current webbased HAI surveillance systems and current state of HAI surveillance and management, realtime automatic information system platform design was demonstrated based on the idea of realtime automatic surveillance, hardware and software requirement, and basic function design. Results The framework protocol of realtime automatic information system has been designed and four basic requirements must be met: the platform for massive data storage and processing, the device for data transmission between hospital network and the network outside the hospital, uniform reporting table for HAI surveillance, and information system based on the network outside the hospital, such as the internet. The system had three main functions: data sending automatically, data analysis and sharing, decision supporting and early warning.ConclusionThere is a clear idea for the design of webbased realtime automatic surveillance and management of HAI platform, which is very powerful, accurate and reliable. The establishment of this platform will greatly reduce the cost of HAI surveillance and improve the quality of HAI management.