ObjectiveTo realize the impact of hepatitis A or E viral superinfection on liver function and prognosis of patients with chronic hepatitis B(CHB).Methods45 CHB patients with hepatitis A superinfection (CHB+HA group), 47 CHB patients with hepatitis E superinfection(CHB+HE group),and 60 patients with CHB alone (CHB group) were studied and compared. HBsAg, antiHBs, HBeAg, antiHBe, antiHBc, antiHAV IgM and antiHEV IgM were detected by enzymelinked immunosorbent assay(ELISA), HBV DNA was detected by fluorescent quantitative polymerase chain reaction (FQPCR). Liver function and prothrombin time(PT) were detected.ResultsCompared with CHB+HA and CHB groups, in CHB+HE group, the total bilirubin(TB) and aminotransferase increased, albumin(ALB) decreased, the time of normalization of TB and aminotransferase as well as PT prolonged, morbidity and mortality of severe hepatitis increased (P<0.05). In CHB+HA group, TB and aminotransferase increased, the time of normalization of TB and aminotransferase prolonged significantly compared with CHB group(P<0.05), but difference in decrease in ALB, prolongation of PT, and morbidity and mortality of severe hepatitis between two groups were not significantly different(P>0.05).ConclusionThe superinfection of hepatitis A has certain impact on TB and aminotransferase; chronic hepatitis B patients superinfected with hepatitis E virus have more severe hepatic damage and higher mortality.