ObjectiveTo evaluate the efficacy of combination therapy of ribavirin and xiyanping on the treatment of handfootmouth disease (HFMD).MethodsFrom April to July 2012,one hundred and eightysix cases of HFMD admitted to a hospital were randomly divided into two groups, 90 patients in control group received ribavirin intravenous drip (10 mg/kg·d),and 96 patients in treatment group added xiyanping intravenous drip (5-10 mg/kg·d) in addition to ribavirin,all were once a day for 7 days. The efficacy, length of hospital stay, and adverse reactions and so on in two groups were observed after treatment.ResultsTotal efficacy rate was 92.71% （89/96）in treatment group and 68.89% （62/90）in control group（χ2=7.98，P＜0.05）.Defervescence time,deflorescence time, oral ulcer healing time and length of hospital stay in treatment group were significantly shorter than those in control group（［2.51±1.12］ d vs ［4.29±1.61］d，t=8.80;［2.68±0.82］ d vs ［3.89±1.33］d，t=6.40; ［3.78±1.23］d vs ［4.91±1.77］d，t=5.08; ［4.82±1.48］d vs ［7.12±1.89］d，t=9.27;all P<0.05）.ConclusionThe combination of ribavirin and xiyanping has a better clinical efficacy on ordinary cases of HFMD, and adverse reaction is little.