ObjectiveTo explore the risk factors for healthcareassociated infection (HAI) in hospitalized patients at an orthopaedics department of a hospital, and provide reference for the prevention of HAI. MethodsClinical data of 3 776 hospitalized patients between January 2011 and December 2012 were reviewed retrospectively.ResultsA total of 79 cases (2.09%) of HAI occurred, the most common infection site was lower respiratory tract（30.38%）,followed by surgical site（26.58%）; 79 pathogenic strains were isolated, 58 （73.42%）of which were gramnegative bacilli, 21（26.58%） were grampositive cocci. The risk factors for HAI in patients with orthopaedics diseases were age, length of hospital stay, surgery(types and modes), and associated diabetes mellitus.ConclusionOrthopaedics patients are vulnerable to respiratory tract and surgical site infection, corresponding measures should be taken to reduce the incidence effectively.