Objective To investigate the incidence of adverse drug reaction (ADR) in patients in a hospital, and evaluate ADRrelated factors, so as to provide references for the prevention of ADR and reducing of risk factors in drug use. Methods223 clinically reported ADR cases were collected from January 1, 2011 to December 31, 2011, patients' age, types and administration routes of drugs relating to ADR, and ADRinvolved organs and systems were analyzed.ResultsOf 223 patients with ADR, 211（94.62%）received intravenous drip， 3 received intravenous injection， 2 received intramuscular injection，and 7 received oral administration. ADR mainly occurred within 1-30 minutes after taking the medicines， 39（17.49%）occurred within 1-4 minutes，45（20.18%）within 5-9 minutes，80（35.87%）within 15-29 minutes. Of organ or system involved by ADR, skin and its appendage damages were common (93 cases),followed by gastrointestinal tract (62 cases)and systemic damage (45 cases); single organ and systemic damage were most common (184 cases,82.51%). 123 cases (55.16%) of ADR were caused by antimicrobial use, 60 cases (26.91%) were induced by Chinese medicine injection; Of top 10 ADRinducing medicines,7 were antimicrobial agents and 3 were traditional Chinese medicine injections, levofloxacin lactate and sodium chloride injection ranked first(23 cases,10.31%).ConclusionThe occurrence of ADR is related to multiple factors, reporting and surveillance of ADR should be strengthened, the use of antimicrobial agents and traditional Chinese medicine should be rational, thereby reduce the occurrence of ADR.