ObjectiveTo evaluate the clinical value of plasma procalcitonin and Ddimer measurements in estimating the prognosis of patients with sepsis. MethodsAccording to prognosis,68 patients with sepsis were divided into survival group and death group，levels of procalcitonin and Ddimer, and acute physiology and chronic health evaluation II (APACHE II) of two groups of patients were compared, predictive value of above markers in estimating the prognosis of patients with sepsis were evaluated.ResultsOf 68 patients with sepsis, 28 survived and 40 died,mortality was 58.82%. There were significant differences in levels of procalcitonin and Ddimer,as well as APACHE II between two groups(both P<0.05), death group were all higher than survival group.Procalcitonin and Ddimer level were positively correlated with APACHE II score（P＜0.05）.ConclusionProcalcitonin, Ddimer level and APACHE II score can be used to evaluate condition of patients with sepsis as well as the prognosis of disease.