ObjectiveTo explore the investigation and control  method  for the  epidemic of surgical site infection(SSI)in a hospital. MethodsData of orthopedics patients receiving clean wound orthopedics operation were analyzed retrospectively, and effective measures were taken to control the epidemic of HAI. Results From June to August 2012, a total of 312 patients received clean wound  orthopedics operation,7 (2.24%) SSI cases occurred. SSI rates during the same period from 2009 to 2012 were significantly different(P<0.05), and was the highest in 2012. HAI management staff reviewed patients’ medical records,communicated  with staff in orthopedics department, and put forward  advice for SSI control; orthopedics department worked out and implemented detailed infection control measures. The subsequent surveillance showed that the prevalence of SSI in orthopedics ward decreased to 0.38%，infection outbreak  was effectively controlled. ConclusionHAI management department played an important role in the finding and control of HAI outbreak. Scientific analysis on monitored data and proper measures adopted by HAI management department and clinical department can effectively control HAI outbreak.