ObjectiveTo evaluate the effect of FOCUSPDCA program(find, organize, clarify, understand, select, plan, do, check, act )  on the prevention and control of  catheterrelated blood stream infection (CRBSI) in an intensive care unit(ICU). MethodsProcess of  central venous catheterization and nursing care were analyzed by using FOCUSPDCA program, and the causes for CRBSI were found out ; a continuous quality improvement  (CQI) team was established to provide training for ICU nurses, and the process was improved and supervised, virtuous circle was created. ResultsIncidence of CRBSI decreased from 8.29‰ before FOCUSPDCA intervention(JanuaryDecember,2010) to 3.20‰ after FOCUSPDCA intervention(January 2011—December 2012),the difference was significant (χ2=14.6，P＜0.001）.  ConclusionFOCUSPDCA program is effective for controlling the incidence of CRBSI.