ObjectiveTo evaluate the relationship between cytotoxinassociated geneA (CagA) seropositive  of Helicobacter pylori (H. pylori )infection and risk of atherosclerotic cerebral infarction(ACI). MethodsRelated literatures were researched through literature retrieval , literatures were obtained  by uniformed  criteria of inclusion and exclusion, and Meta analysis was performed with RevMan 4.2 software.ResultsA total of 10 literatures which met the inclusion criteria were retrieved, all were casecontrol study, case group  included 907 studied subjects, and control group included 966 subjects; the included population were divided into   Chinese subgroup and European Caucasian subgroup. Meta analysis of CagA seropositive  of H. pylori infection and risk of ACI  revealed that OR of the overall population,Chinese subgroup,and European Caucasian subgroup was  2.66( 2.17-3.26),2.60(1.93-3.49), and 2.71( 2.05-3.59) respectively; Meta analysis of CagA seronegative  of H. pylori infection and risk of ACI  revealed that OR of the overall population, Chinese subgroup, and European Caucasian subgroup was 0.74（0.49-1.10）,0.81（0.45-1.48）, and 0.64（0.37-1.09）respectively. The funnel plot and failsafe number showed that there was no significant publication bias, the result was stable  and reliable.ConclusionChronic infection caused by CagA seropositive strains of H.pylori may be one of the risk factors of CAI, whether the eradication treatment of seropositive strains of H.pylori influences the process of atherosclerotic diseases like CAI needs to be further studied.