ObjectiveTo explore the efficacy and adverse reactions of diminishing scheme of cefaclor sustained release tablets in the treatment of recurrent urinary tract infection(RUTI). Methods60  RUTI patients in a hospital were divided into treatment group(n=30) and control group (n=30), patients in treatment group were treated with diminishing scheme of cefaclor sustained release tablets, patients in control group were treated with diminishing scheme of levofloxacin tablets, clinical therapeutic efficacy and adverse reactions of  two groups  were observed. ResultsThe curative rate in treatment group was higher than control group （［80.00%,n=24］vs ［53.33%,n=16］） (χ2=4.80，P=0.028）. The incidence of RUTI in treatment group was lower than control group (［6.67%，n=2］ vs ［26.67%，n=8］)（χ2=4.32，P=0.038）. Incidence of adverse reactions in treatment group was lower than control group (16.67% vs 50.00%)（χ2=7.50，P=0.006）. ConclusionThe diminishing scheme of cefaclor sustained release tablets in the treatment of RUTI has good curative efficacy, low recurrence rate, fewer adverse reactions, and can be used for the treatment of recurrence of RUTI.