ObjectiveTo evaluate the effect of wound protector on preventing incisional wound infection following class ⅢⅣincision abdominal operation. MethodsPatients who had undergone class ⅢⅣincision abdominal operation from January 2013 to December 2014 were divided into  trial group and  control group according to whether they had used wound protector ,  incidence of postoperative incisional wound infection between two groups were compared. ResultsA total of 310 patients were monitored, 150 cases in  trial group, and 160 cases in control group. Incidence of incisional wound infection in trial group was significantly lower than control group (4.00% ［n=6］ vs  11.88%［n=19］,χ2＝6.48，P＜0.05）. The average operation time and length of hospital stay in trial group were both shorter than control group （［42.10±3.30］ min vs ［58.30±4.10］ min,  P＜0.05; ［7.00±2.20］d vs ［10.00±3.50］d , P＜0.05）, score of pain assessment of incision in trial group was lower than control group（［2.00±1.70］vs ［3.00±1.80］, P＜0.05）. ConclusionWound protector can effectively reduce the incidence of incisional wound infection following class ⅢⅣincision abdominal operation.