ObjectiveTo explore the status and influencing factors of surgical site infection (SSI) following laparoscopic surgery in patients in department of general surgery, so as to take effective measures to reduce SSI.MethodsActive monitoring method was used to survey SSI among 401 patients undergoing laparoscopic surgery from January 1, 2013 to December 31, 2013, univariate analysis and multivariate analysis on risk factors for SSI were conducted.ResultsOf 401 investigated patients, 12 (2.99%) developed SSI. Univariate analysis showed that risk factors for SSI in patients with laparoscopic surgery were  elderly patients, emergency operation, infected wound, gastrointestinal tract operation, and grade Ⅳof ASA score (all P＜0.05).Multivariate logistic regression analysis revealed that elderly patients (OR, 5.02［95%CI,1.38-30.25］), emergency operation (OR,4.37 ［95%CI,1.96-28.55］), infected wound (OR,7.27［95%CI,2.54-25.05］), and gastrointestinal tract operation  (OR,8.13 ［95%CI,1.38-18.33］)were high risk factors for SSI following laparoscopic surgery(all P＜0.05).ConclusionThere are multiple factors influencing SSI after laparoscopic surgery, diversified prevention and control measures can effectively reduce the incidence of postoperative SSI.