ObjectiveTo analyze the distribution and change of antimicrobial resistance of common pathogenic bacteria from geriatric ward, and provide  reference for rational use of antimicrobial agents.MethodsSpecimens from hospitalized patients in a geriatric ward from 2009 to 2013 were analyzed, the isolated pathogenic bacteria and antimicrobial resistance of bacteria were analyzed statistically.ResultsFrom 2009 to 2013, a total of 7 426 pathogenic bacteria were isolated, the percentage of gramnegative bacilli, grampositive cocci, and fungi were  90.96%（n=6 755），7.23%（n=537），and 1.81%（n=134）,respectively. The top 5 detected bacteria  were  Pseudomonas aeruginosa (39.16%), Escherichia coli (16.47%), Stenotrophomonas maltophilia (10.65%), Klebsiella pneumoniae (7.22%), and Acinetobacter baumannii (6.21%), these strains were mainly isolated from sputum(94.15%,n=5 573). Resistance rates of Acinetobacter baumannii to all detected antimicrobial agents, Pseudomonas aeruginosa to 8 kinds of common antimicrobial agents (piperacillin / tazobactam, ceftazidime, aztreonam, imipenem, et al), Escherichia coli to 5 kinds of common antimicrobial agents (piperacillin / tazobactam, cefoperazone/sulbactam, aztreonam, levofloxacin, and ciprofloxacin), and Stenotrophomonas maltophilia to ceftazidime and levofloxacin all showed an increased tendency (all P<0.01); there was no obvious change in resistance rates of Klebsiella pneumoniae to all detected antimicrobial agents (all P>0.05).ConclusionThe major pathogenic bacteria isolated from geriatric ward is Pseudomonas aeruginosa, which is highly resistant to multiple antimicrobial agents, antimicrobial agents should be chosen based on antimicrobial susceptibility testing results.