ObjectiveTo evaluate the effect of bundle intervention measures on preventing ventilatorassociated pneumonia (VAP).MethodsPatients who were admitted to an intensive care unit(ICU) of a hospital from January 2012 to December 2013 were monitored, patients from January to December 2012  were as control group,  while from January to December 2013 were as intervention group (bundle intervention measures were implemented). Usage rate of ventilators and incidence of  VAP  between two groups were compared.ResultsA total of 4 560 patients were monitored, 2 608  in  intervention group and 1 952 in control group. Usage rate of ventilators in intervention group was lower than control group (53.95% vs 61.17%； χ2=65.756，P＜0.01）. Incidence of VAP per 1 000 ventilator days in intervention group was lower than control group (13.00‰ vs 19.56‰； χ2=4.649，P=0.031）. Percentage of lateonset VAP per 1 000 ventilator days in tervention group was higher than control group（41.82‰ vs 24.59‰）.ConclusionBundle intervention measures are helpful for reducing the incidence of  VAP in ICU patients.