ObjectiveTo analyze risk factors and complication characteristics of healthcareassociated infection(HAI)  in patients with lung cancer, and provide evidence for the formulation of HAI management strategy. MethodsHAIrelated articles were retrieved from China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database, Vip database,PubMed, and Embase, all data were conducted Metaanalysis. ResultsA total of 19 articles involving 8 069 hospitalized patients with lung cancer (1 280 had HAI) were included. Metaanalysis on combined values of medical factors for HAI were as follows:  OR(95%CI) of antitumor therapy(radiotherapy and chemotherapy)， number of chemotherapy (≥2 times), antimicrobial prophylaxis, immunosuppressant therapy, and invasive operation were 3.13(1.82,5.39), 9.20(3.04,27.87), 3.23(1.77,5.91), 2.00(1.56,2.57), and 2.28(1.81,2.88), respectively； Metaanalysis on combined values of complication factors for HAI were as follows:  OR(95%CI) of pulmonary diseases，chronic obstructive pulmonary disease (COPD)， diabetes, renal dysfunction， malnutrition, hypoalbuminemia, neutropenia,and leukopenia were 2.65 (1.74, 4.02), 2.40 (1.76, 3.27), 2.25(1.85, 2.73), 2.56(1.18, 5.52), 5.51 (1.70, 17.89), 2.05(1.56, 2.70), 3.38(1.40, 8.18), and 2.10 (1.22, 3.62), respectively. ConclusionHAIrelated factors of medical treatment and complications in patients with lung cancer are diversity, risk factors for HAI in patients with lung cancer are antitumor therapy， immunosuppressant therapy, antimicrobial prophylaxis, invasive operation, pulmonary diseases， COPD，diabetes, renal dysfunction， malnutrition, hypoalbuminemia, neutropenia, and leucopenia.