ObjectiveTo investigate infection status and distribution characteristics of human immunodeficiency virus (HIV) infection among voluntary blood donors in Xiangyang area in 2009-2014, and provide evidence for recruiting blood donors from lowrisk population.MethodsBlood specimens of 326 856 voluntary blood donors in Xiangyang area between January 2009 and December 2014 were detected antiHIV with enzyme linked immunosorbent assay(ELISA), positive specimens in HIV screening were performed confirmatory testing, epidemiological analysis was conducted on the positive detection results.Results41 (0.13‰) voluntary blood donors were confirmed positive for HIV in Xiangyang area, positive rate among each year was significantly different (χ2=27 801.87，P<0.01). Except marital status and infection routes, difference in positive rates among donors of different gender, age, area, occupation, educational attainments, and number of blood donation were all significantly different(all P<0.01). Among HIVinfected voluntary blood donors, 87.80% were male, 41.46% and 31.71% were aged between 18-25 and 36-45 respectively，56.10% were through heterosexual transmission, and 43.90% were through male homosexual transmission. The percentage of workman and public service personnel infected with HIV were high, accounting for 21.95% and 17.07% respectively，60.97% of confirmed positive HIV were from city area, 56.10% only received junior middle school/technical secondary school education, 65.85% of HIVinfected persons were infected at the initial donation.ConclusionIn order to ensure blood safety, blood center should increase publicity efforts, carry out health consultation before blood donation, and recruit blood donors from lowrisk populations, nucleic acid detection should be carried out to shorten HIV detection window period.