ObjectiveTo investigate the incidence of surgical site infection(SSI) and compliance to bundle intervention measures on SSI following total abdominal hysterectomy in patients in department of gynaecology of a tertiary firstlass hospital, and evaluate the efficacy of bundle intervention measures in prevention and control of SSI.MethodsFrom March 2014 to October 2015, all gynecology patients undergoing total abdominal hysterectomy were as targeted monitored subjects, MarchSeptember 2014 was baseline investigation stage, October 2014 to October 2015 was intervention stage(new bundle intervention measures were performed), compliance to bundle intervention measures and incidence of SSI before and after intervention were compared.ResultsA total of 222 episodes of total abdominal hysterectomy were monitored, the incidence of SSI was 5.86%, the operation P75 time were 2 hours. Compared with the baseline stage, the compliance to most traditional intervention measures improved after intervention, the largest increase in the compliance to interventions was followup after surgery (increased by 64.16%), followed by preoperative perineal disinfection(increased by 39.07%) and hand hygiene(increased by 21.34%). Compliance to new intervention measures was 100.00%. Incidence of SSI following total abdominal hysterectomy after intervention was significantly lower than before intervention(2.27%［3/132］ vs 11.11%［10/90］), difference was significant (χ2=7.583, P＜0.05）.ConclusionTargeted monitoring on SSI following total abdominal hysterectomy can improve compliance to bundle intervention measures and decrease incidence of SSI.