ObjectiveTo investigate the status of safe injection practice in primary medical institutions.Methods55 primary medical institutions in Hubei Province were randomly selected, questionnaire survey on status of safe injection in primary medical institutions was conducted.ResultsA total of 55 questionnaires were distributed, 50(90.91%) valid questionnaires were obtained. All valid questionnaires were from primary level medical institutions of Hubei Province, 16 of which were from community health centers, 17 from township health centers, and 17 from village health clinics. None of 50 primary medical institutions repeatedly used syringe and hemostix, all used disposable sterile syringe, only 7(14.00%) medical institutions used retraction type selfdestructing syringe. Only 5 (10.00%) medical institutions were equipped with hand hygiene facilities and sharps containers, 32 (64.00%) medical institutions didn’t provide sharps containers on treatment carts, 21 (42.00%) injection rooms didn’t install handdrying facilities, 18（36.00%）medical institutions didn’t provide alcoholbased hand rub on treatment carts and didn’t install handdrying facilities in treatment rooms. Of sharp injures among health care workers(HCWs) reported in 2015,114 HCWs sustained 117 times of injuries, 74 cases（63.25%） were caused by ampoule. Of medical waste disposal, there existed some problems,such as leakage and repeated use of sharps box, didn’t close sharps box timely, as well as without providing sharp containers in locations where sharps might be produced.ConclusionThere are a variety of hidden risks of unsafe injection in primary medical institutions, like insufficient facilities and unsafe disposal of medical waste.