ObjectiveTo analyze risk factors for surgical site infection(SSI) in cardiac surgery patients, so as to provide basis for making control measures.Methods215 patients who underwent cardiac surgery in a hospital between January 2012 to December 2014 were investigated, univariate analysis and multivariate logistic regression analysis were used to analyze the related risk factors for postoperative SSI.ResultsThe incidence of postoperative SSI in cardiac surgery patients was 16.28%（35/215）. Univariate analysis showed that the incidence of postoperative SSI was relatively higher in patients aged>65 years, duration of operation>5 hours，continuous operation, preoperative hospitalization time >7 days, irrational perioperative antimicrobial use, as well as patients with underlying diseases such as hypertension and diabetes mellitus. Multivariate logistic regression analysis indicated that the age, duration of operation, continuous operation, preoperative hospitalization time, irrational perioperative use of antimicrobial agents, and patients with underlying diseases were independent risk factors for SSI in patients who underwent cardiac surgery.ConclusionIncidence of SSI is higher in patients with cardiac surgery, preventive measures should be taken to control risk factors such as duration of operation, so as to reduce the incidence of SSI.