ObjectiveTo understand the general selfefficacy level of patients with tuberculosis(TB patients) and its influencing factors, provide evidence for improving the general selfefficacy of TB patients. MethodsAll TB inpatients in a comprehensive pulmonary hospital were conducted facetoface survey through a general questionnaire and general selfefficacy scale, selfefficacy level of TB patients and its influencing factors were analyzed. ResultsMean scale of general selfefficacy of 402 TB patients was (20.4±4.2), of which only 14 cases（3.5%）showed a high level selfefficacy. 163（40.5%）, 225（56.0%）, and 14（3.5%）patients were with low（10～）,medium（20～）, and high（30～） selfefficacy scale. The general selfefficacy level of TB patients was influenced by the course of disease（P<0.001）, residence（P=0.012）, whether or not attended the lecture on tuberculosis education（P=0.034）, whether or not conducted physical exercise（P=0.053，stepwise multiple linear regression analysis: P=0.017）, working status（P=0.027）, No. of hospitalization due to TB（P=0.002）, family economic situation（P=0.027）, and education level（P=0.020）. ConclusionTB patients’ selfefficacy level is low, and the general selfefficacy level and its influencing factors should be assessed by health care workers during the followup for patients, individualized nursing intervention for improving the TB patients’ selfefficacy level should be developed.