ObjectiveTo evaluate the advantage of homemade negative pressure device combined with nanosilver dressing for promoting the healing of infected incision in rats, and explore its clinical curative effect. MethodsInfected incision model rats were randomly divided into conventional treatment group, and simple pressure suction group, pressure suction combined with silver ion dressing group. The healing time and healing area of rats in each group after treatment were evaluated, immunohistochemical and fluorescent quantitative analysis of inflammatory factors in incisional wound tissue were performed. Three methods were applied to patients with surgical site infection(SSI), granulation coverage time, granulation recovery time, and incision healing time of three groups of patients were compared. ResultsImmunohistochemistry and its IOD value, the relative mRNA expression levels of TNFα, IL2, and IL8 in rat wound tissue treated with pressure suction combined with silver ion dressing were all inferior to conventional treatment group and simple negative pressure suction group, difference was statistically significant (P< 0.05); in clinical application, wound healing time, postoperative Creactive protein level, and pain assessment scores in patients treated with pressure suction combined with silver ion dressing were all superior to conventional treatment group and simple negative pressure suction group, difference were all statistically significant (all P< 0.05). ConclusionCompared with conventional treatment method, pressure suction with silver ions dressing treatment can more effectively control SSI, reduce local inflammation of incision, and promote incision healing.