ObjectiveTo understand the pathogenic distribution and epidemiological trend of handfootandmouth disease (HFMD), and provide evidence for the prevention and control of HFMD. MethodsChildren who were diagnosed with HFMD in a hospital between January and December 2015 were investigated, realtime fluorescence PCR was used to detect enterovirus universal type EV, enterovirus 71 (EV71), and Coxsackievirus A16 (CoxA16) in specimens from children with HFMD. Positive rates and distribution of various types of EV among children of different months, genders, age groups, and infection types were analyzed. ResultsA total of 837 throat swab specimens from HFMD children were collected in 2015, 380 (45.40％) of which were EV positive specimens. Virus typing showed that 110 (28.95%), 7 （1.84％）, 6（1.58％）, and 257（67.63％） were positive specimens for EV71, CoxA16, EV71+CoxA16, and other types of EV.  HFMD had a high prevalence since April, reached a peak in MayJune, and remained high incidence in JulyDecember. Positive rates of EV in children of different months were statistically different (P<0.05). The age of onset was mainly in children under 3 years. Positive rates of EV and constitute ratios of different types of EV in children of different age groups were all statistically different (all P<0.05). The positive rate of EV in severe HFMD cases was higher than common cases (65.34% vs 27.06%, P＜0.001）. The proportion of severe cases in children with EV71 infection and other types of EV infection were 90.00% and 60.70% respectively; children with EV71+CoxA16 double infection were all severe cases. Constitute of EV types in children with different infection types was statistically different(P<0.001). ConclusionIn 2015, EV infection in hospitalized children with HFMD in this hospital was mainly caused by other types of EV (nonEV71 and nonCoxA16), the high prevalence season, highrisk population under 3 years of age, and severe cases should be paid high attention, prevention and treatment should be performed well.