ObjectiveTo explore the necessity of opening nephrostomy tube for patients with septic shock following the indwelling doubleJ stent of postpercutaneous nephrolithotomy (PCNL), and provide reference for the treatment of septic shock after PCNL. Methods60 patients with septic shock after PCNL in a hospital from January 1, 2015 to December 30, 2016 were chosen, patients were randomly divided into clipping nephrostomy tube group (clipping group, n=30) and opening nephrostomy tube group (opening group, n=30), clinical data of two groups of patients were collected and analyzed. ResultsAfter 24hour treatment, heart rate (HR), mean arterial pressure (MAP), oxygen saturation (SpO2), serum lactate (Lac), and hourly urine volume all improved in both groups of patient compared with pretreatment(all P<0.05); HR, MAP, SpO2, Lac, and hourly urine volume in opening group after 24hour treatment were all significantly different from clipping group (all P<0.05). Levels of serum procalcitonin (PCT) and Creactive protein (CRP) in two groups after 3day treatment decreased significantly compared with pretreatment (both P<0.05); PCT and CRP levels in opening group after 3day treatment were both significantly lower than clipping group (both P<0.05); cure rate of two groups were both 100.00%, hospitalization time and extubation time in opening group were both shorter than clipping group, and cost was less than clipping group, difference were all significant(all P<0.05). ConclusionOpening nephrostomy tube on the basis of indwelling doubleJ stent is necessary for patients with septic shock after PCNL.