ObjectiveTo improve the qualified rate of cleaning of loaner orthopedic surgery instruments by application of quality control circle(QCC). MethodsQCC activity was carried out in a hospital from May to October 2016, onsite assessment of cleaning quality was performed by two circle members, causes of unqualified cleaning result of loaner orthopedic surgery instruments were recorded, the qualified result of loaner orthopedic surgery instruments before QCC activity (MayJune 2016) and after QCC activity (SeptemberOctober 2016) was compared. ResultsBefore QCC activity, there were 1 667 packages of loaner instruments, 1 415 were qualified for cleaning, qualified rate was 84.88%; after activity, there were 1 673 packages of loaner instruments, 1 655 were qualified for cleaning, qualified rate was 98.92%, difference was statistically significant between two groups (P<0.01), qualified rate increased to 14.04%, target achievement rate was 116%.ConclusionApplication of the scientific tool of QCC can improve the qualified rate of cleaning of loaner orthopedic surgery instruments.