ObjectiveTo analyze risk factors for death in elderly patients with ventilatorassociated pneumonia(VAP).MethodsPatients aged≥60 years and with VAP in a hospital from April 2011 to February 2017 were surveyed, clinical data of patients, including basic condition, infection status, and prognosis were collected, risk factors for death were analyzed.ResultsThere were 682 elderly patients with VAP, 198 (29.03%) died. There were 8 independent risk factors for death in elderly VAP patients: APACHE II score>15 points（OR, 2.482 ［95%CI, 1.473-4.183］）, mechanical ventilation>15 days（OR, 2.526 ［95%CI, 1.661-3.840］）, multidrugresistant organism infection（OR, 3.379 ［95%CI, 2.008-5.686］）, fungal infection（OR, 3.414 ［95%CI, 1.830-6.370］）, glucocorticoid use（OR, 2.075［95%CI, 1.265-3.403］）, serum albumin concentration＜35 g/L（OR, 2.129［95%CI, 1.386-3.268］）, number of organ damage≥3（OR, 3.438［95%CI, 2.165-5.459］）, and blood sugar≥10 mmol/L（OR, 1.744［95%CI, 1.106-2.751］）.ConclusionMortality of elderly patients with VAP is related to multiple factors, comprehensive prevention and control measures should be taken to interfere the main risk factors and reduce the mortality.