ObjectiveTo comprehensively evaluate the quality of healthcareassociated infection(HAI) management in a tertiary firstclass hospital in Tianjin City from 2012 to 2016, understand control status of HAI, and provide an objective basis for the evaluation of HAI management. MethodsData of HAI management in a tertiary firstclass hospital in Tianjin from 2012 to 2016 were collected, analytic hierarchy process (AHP) method was adopted to calculate each dimension weight of the index system, Topsis method was adopted to comprehensively evaluate HAI management. ResultsThe evaluation of HAI management quality in this hospital was the best in 2013(C=0.6012), and worst in 2015(C=0.3937), which was consistent with the actual situation of hospital.ConclusionAHPTopsis method is used to comprehensively evaluate the quality of HAI management, the results are true and credible, it has a certain guiding role in evaluating the quality of HAI management and innovation of HAI management methods.