Objective To understand the occurrence regularity and epidemic features of notifiable infectious diseases (NIDs) among children in a tertiary general hospital, provide scientific basis for the triage and referral of infectious diseases, as well as formulation of prevention and control measures of healthcare-associated infection (HAI) among children in a general hospital. Methods Descriptive epidemiological method was used to analyze the epidemiological data of reported NIDs in children in the hospital from 2013 to 2017. Results From 2013 to 2017, 1 170 children with infectious diseases were reported, the average annual reporting rate was 5.81‰, 670 cases (57.26%) were males and 500 (42.74%) were females. The population distribution was mainly students (n=503, 42.99%) and scatter lived children (n=433, 37.01%). The reported cases were mainly concentrated in the second quarter of each year, the top three diseases were chickenpox (n=423, 36.15%), hand-foot-mouth disease (n=332, 28.38%), and mumps (n=199, 17.01%). Conclusion Infectious disease in children is an important link in the prevention and control of infection in tertiary general hospitals, the report of infectious diseases of hand-foot-mouth disease, chickenpox and mumps, as well as implementation of prevention and control measures of HAI should be strengthened.