Objective To explore the effect of quality control circle (QCC) activities on reducing pulmonary infection in patients with severe craniocerebral injury. Methods Patients with severe craniocerebral injury and treated in the neurosurgery department of a hospital were selected for research, patients who were hospitalized from February 2016 to March 2017 were in pre-intervention group, QCC activities were initiated from April 2017, and patients who were hospitalized from April 2017 to May 2018 were in post-intervention group. Incidence of pulmonary infection and satisfaction for nursing service in patients as well as duration of antimicrobial use in patients with pulmonary infection were compared between two groups. Results A total of 224 patients with severe craniocerebral injury were investigated, each group were 112 cases. Incidence of pulmonary infection in post-intervention group was lower than pre-intervention group (21.42% vs 47.32%), duration of antimicrobial use in post-intervention group was shorter than pre-intervention group ([6.45±1.65] d vs[13.02±2.46] d), satisfaction for nursing service in post-intervention group was higher than pre-intervention group (82.14% vs 63.39%), difference were all statistically significant (all P<0.05). Conclusion Application of QCC is helpful to reduce the incidence of pulmonary infection in patients with severe craniocerebral injury, and has a good effect on promoting the recovery of patients and improving nursing satisfaction.