Objective To explore the application value of seamless management mode in the management of loaner devices and implants in central sterile supply department (CSSD). Methods 2 762 loaner devices and implants received with conventional method by a hospital from January 1 to December 31, 2017 were selected as control group, 1 349 loaner devices and implants received after the implementation of seamless management mode from January 1 to June 30, 2018 were as intervention group, nurses' overtime, backwash rate and loss rate of devices were compared between two groups. Results The overtime time of nurses in intervention group was shorter than that of control group ([125.7±36.8]min vs[29.5±43.2]min, t=28.116, P<0.001). In the control group, loaner devices and implants were placed for a long time after operation, management was not enough, nurses didn't check and pack in time after cleaning, which resulted in confusion and loss of devices. In intervention group, after standardized the process, all loaner devices and implants could be delivered to CSSD and handed over the prescriptive time, and all were cleaned by automatic spray cleaner. Backwash rate and loss rate of devices were both lower than those in control group (0.74% vs 1.74%; 0.30% vs 0.91% respectively). Conclusion Seamless management mode applied to the management of loaner devices and implants in CSSD can improve the management and cleaning quality of loaner devices and implants, and improve the work efficiency of nurses.