The emergence of "superbugs" resistance will bring us into "the post-antimicrobial era". In the face of the increasingly serious bacterial resistance, finding new antimicrobial agents and therapy options has become an urgent problem to be solved. This paper elaborates in detail the advantage of bacteriophage therapy by consulting a large number of successful cases of bacteriophage therapy at home and abroad, fully illustrates that bacteriophage lysis of drug-resistant strains for bacterial disease therapy is an effective method, points out advantage and disadvantage of bacteriophage therapy technology, and puts forward the future development direction.