Objective To analyze the influencing factors for recurrent pulmonary infection in coma patients in intensive rehabilitation unit. Methods Clinical data of hospitalized patients in the intensive rehabilitation unit of rehabilitation medicine department of a hospital from January 2016 to December 2019 were retrospectively analyzed, basic condition, injury, underlying diseases, laboratory tests and rehabilitation intervention were compared between patients in recurrent pulmonary infection group and non-pulmonary infection group in the rehabilitation department. Results A total of 269 patients were investigated, and 167 cases had recurrent pulmonary infection. Logistic regression analysis showed that low serum albumin (95%CI:0.750-0.883, OR=0.814), GCS<8 (95%CI:0.176-0.571, OR=0.317) and coma time ≥ 3 weeks (95%CI:1.637-10.752, OR=4.196) were independent risk factors for recurrent pulmonary infection in coma patients. A total of 245 pathogens were isolated from 269 patients, the top three were Pseudomonas aeruginosa (77 strains, 31.43%), Acinetobacter baumannii (70 strains, 28.57%), and Klebsiella pneumoniae (40 strains, 16.32%); the main multidrug-resistant organisms were Acinetobacter baumannii (63 strains, 49.22%), Pseudomonas aeruginosa (29 strains, 22.66%), and Klebsiella pneumoniae (20 strains, 15.62%). Conclusion For coma patients in intensive rehabilitation unit, improving their consciousness, correcting and preventing hypoalbuminemia and shortening hospital stay as far as possible are conducive to reducing the incidence of pulmonary infection.