Objective To explore epidemic characteristics of asymptomatic coronavirus disease 2019 (COVID-19) -infected persons. Methods Clustered epidemics involving asymptomatic infected persons in Henan Province were collected and summarized through Chinese Disease Control and Prevention System, epidemic characteristics were analyzed, differences in epidemic characteristics between asymptomatic infected persons and confirmed cases of COVID-19 were analyzed. Results A total of 257 clustered epidemics were reported, 41 of which involved 84 asymptomatic infected persons, accounting for 74.34%(84/113) of asymptomatic infection in the whole province. The clustered epidemics of asymptomatic infected persons distributed in 11 prefectures, involving 208 cases of COVID-19, each epidemic involved an average of 5.07 (2-19) COVID-19 infection cases, 16 (39.02%) had at least 5 COVID-19 infection cases. The discovery of asymptomatic infection was mainly based on clustered epidemic investigation, diagnosis time was later than that of COVID-19 confirmed cases. The proportion of asymptomatic infection among COVID-19 infection in various cities in Henan Province was the highest in Shangqiu City(26.02%). Asymptomatic infected persons and COVID-19 confirmed cases were statistically different in gender distribution and epidemiological history (both P>0.05); differences in constituent ratios of age and occupational distribution were both statistically significant (both P<0.05), asymptomatic infected persons ≤ 40 years old accounted for 58.33%, students and children accounted for 28.57%, and confirmed cases accounted for 21.77% and 4.03% respectively. Conclusion The age and occupational distribution of asymptomatic infected persons are different from those diagnosed with COVID-19. Investigation on clustered epidemic is the main way to find asymptomatic infected persons, effective isolation management of close contacts is the correct and effective prevention and control measure.