Objective To explore strategies on sanitary quality management on coronavirus disease 2019(COVID-19) buffer rooms of intensive isolation wards. Methods Self-made inspection forms were used from February 8 to March 6, 2020, sanitary quality management of buffer rooms of COVID-19 intensive isolation wards in a hospital were selected randomly before implementation and at day 15, day 21, and day 28 after implementation of intervention measures. There was 2 points for each item in the form, 10 items in total, effect of intervention measures was evaluated according to scores. Results Before the implementation of intervention measures, score of sanitary quality management in buffer rooms was (9.15±1.80), on the 15th, 21st and 28th day after the implementation of intervention measures, scores were (16.57±2.71), (17.07±2.10) and (19.27±1.13) respectively, difference was statistically significant before and after implementation (P<0.05). Scores in implementing emergency power supply and emergency lighting, as well as automatically switching on power system in case of emergency before and after implementation of intervention measures was not significantly different (P=0.11). scores of implementation of other sanitary quality management measures in buffer rooms were all higher than those before implementation, differences were all statistically significant (all P<0.05). Conclusion During COVID-19 epidemic period, implementation of standardized cleaning process, rational arrangement of commuter time, adequate supplies, good facilities, and strengthened training of personnel are effective measures to improve the sanitary quality of buffer rooms, which is essential to ensure the safety of patients and health care workers.