Objective To analyze the epidemiological characteristics of coronavirus disease 2019(COVID-19) cases of health care workers(HCWs) and family-related cases in a hospital, and provide reference for formulating prevention and control strategies. Methods The three-dimensional distribution, clinical characteristics and contact history of 4 clustered epidemics in a hospital were analyzed by descriptive epidemiological method. Results There were 14 COVID-19 cases of HCWs in the hospital, and 11 cases of family members were involved, the median age of all cases was 38 (23-76) years old, ratio of male to female was 0.79:1. The median of shortest and longest incubation period of all cases was 4 (0-9) and 7 (3-14) days respectively. Interval from the disease onset to medical consultation of all cases was 2 (0-9) days, among which HCWs cases was 1.5 (0-8) days, family member cases was 3 (1-9) days. The first cases of 4 COVID-19 clustering epidemics were all related to Wuhan. Conclusion This event was composed of 4 COVID-19 clustering epidemics, 3 of which were spread by family members, 1 was spread by colleagues in hospital mixed with family members.