Objective To explore the anti-fogging effect of several anti-fogging methods on medical goggles. Methods Goggles were treated with four methods:anti-fogging spray (swimming goggle special use), iodophor smearing, hand sanitizer smearing, and detergent smearing, 10 pairs of goggles were treated with each anti-fogging method respectively, health care workers(HCWs) began to work in COVID-19 isolation ward after wearing treated goggles, fogging of goggles after 2, 4 and 6 hours of work was investigated, anti-fogging effect of four methods was compared. Results Fogging status of four anti-fogging methods in different periods was significantly different (all P<0.05). Anti-fogging spray method was not ideal, HCWs wore goggles for 2 hours and 7 pairs of goggles fogged, wore goggles for 6 hours and 10 pairs of goggles all fogged; iodophor smearing was slightly better, HCWs wore goggles for 2 hours and 2 pairs of goggles fogged, wore goggles for 6 hours and 7 pairs of goggles fogged; hand sanitizer and detergent smearing had better anti-fogging effect, HCWs wore goggles for 2 hours, no goggles fogged, wore goggles for 6 hours, 3 and 2 pairs of goggles fogged respectively. Conclusion Hand sanitizer and detergent smearing can be used to prevent fogging of medical goggles.