Since December 2019, the epidemic of coronavirus disease 2019(COVID-19) in Wuhan has escalated into a national public health emergency, in order to focus on treatment of patients with COVID-19, the government of Wuhan urgently built a Huoshenshan Hospital. The importance of imaging examination determines the important role of radiology department in relevant treatment. By the end of February 20, through summary on relevant experience of prevention and control in radiology department in Wuhan Huoshenshan Hospital since its smooth and efficient operation for 18 days, prevention and control as well as workflow during COVID-19 epidemic period is explored, so as to provide experience and reference for peers in radiology department.