Coronavirus disease 2019(COVID-19) has been developing rapidly since December 2019, the number of isolation wards for observation and isolation wards for patients with COVID-19 in some medical institutions is far from satisfying the requirement of receiving and treating patients as much as possible. According to the original building layout, it is necessary to reconstruct existing common wards into isolation wards, so as to relieve rapidly the contradiction between supply and demand. This paper discusses the site choice, scheme design and key issues that need to be paid attention during the reconstruction of existing common wards into isolation wards, so as to provide reference for similar reconstruction.