Sepsis is a kind of critical disease caused by a variety of causes with high mortality, which leads to high mortality of patients in intensive care unit. Thrombocytopenia is very common in patients with sepsis, the greater the reduction, the higher the mortality of patients. Therefore, clarifying the pathogenesis of sepsis-related thrombocytopenia and selecting appropriate methods to correct thrombocytopenia in time is of great significance to improve the prognosis of patients. In this paper, research status of pathogenesis and treatment of sepsis-related thrombocytopenia is reviewed.