The role of IL-23/Th17 pathway in the development of HBV-related liver diseases
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1.The NHC Key Laboratory of Drug Addiction Medicine, Department of Infectious Diseases and Hepatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China;2.School of Public Health, Kunming Medical University, Kunming 650500, China

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    Abstract:

    Interleukin-23 (IL-23) has an important relationship with chronic inflammation, researches on IL-23 are mainly focused on autoimmune diseases, some IL-23 antagonists have been used in clinical practice. For hepatitis B virus(HBV) infection-related chronic liver diseases (CLD), most studies have shown that the expression of serum IL-23 is elevated, and it may play a pro-inflammatory effect together with Th17 cells in HBV-related CLD. Current researches on IL-23 and HBV infection are mainly correlation study of clinical data, there is little exploration on mechanisms. This paper summarizes the possible mechanism of IL-23/Th17 pathway in HBV-related CLD in relevant domestic and foreign studies in recent years.

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赵寅洲,游晶,李静,等. IL-23/Th17通路在HBV相关肝脏疾病发生发展中的作用[J].中国感染控制杂志英文版,2021,(11):1056-1061. DOI:10.12138/j. issn.1671-9638.20218179.
Yin-zhou ZHAO, Jing YOU, Jing LI, et al. The role of IL-23/Th17 pathway in the development of HBV-related liver diseases[J]. Chin J Infect Control, 2021,(11):1056-1061. DOI:10.12138/j. issn.1671-9638.20218179.

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History
  • Received:January 26,2021
  • Revised:
  • Adopted:
  • Online: April 26,2024
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