Hypervirulent Klebsiella pneumoniae (hvKP) has become a pathogen of global concern, with strong virulence, more likely to cause community-associated infection, patients infected with hvKP have poor prognosis and high mortality. What is worrying is that high antimicrobial resistance hvKP has emerged, which presenting new challenge to clinical anti-infective treatment. This paper reviews the clinical identification and major virulence factors of hvKP, as well as the overlapping expression of antimicrobial-resistant and hypervirulent strains.