Objective To investigate the change in antimicrobial resistance of carbapenem-resistant Klebsiella pneumoniae (CRKP) in China. Methods Data of CRKP in report of China Antimicrobial Resistance Surveillance System(CARSS) from 2014 to 2019 were analyzed, change in antimicrobial resistance of CRKP in different areas, different levels of hospitals, different specimen sources, different age groups, and different departments were compared. Results Isolation rate of CRKP in China rose from 6.4% in 2014 to 10.9% in 2019. In 2019, the highest isolation rates of CRKP were in Henan Province and Shanghai City, which were 32.8% and 28.7% respectively, and the lowest rate was 0.6% in Xizang; in 2019, isolation rates of CRKP in children's hospitals, tertiary hospitals and secondary hospitals were 14.0%, 11.6% and 5.5% respectively; isolation rate of CRKP from patients in intensive care unit was the highest (23.0%), which was higher than those of other hospitalized patients, patients in outpatient department and emergency department. Conclusion Isolation rate of CRKP in China is on the rise, there are differences among different area and departments.