Objective To explore the promotion of informationized quality traceability management(QTM) in hospital central sterile supply departments (CSSDs) in China. Methods According to the basic requirements of information system in Central sterile supply department (CSSD)-Part 1: Management standard WS 310.1-2016, informationized QTM of CSSDs was investigated through sampling survey method by Disinfection and Supply Professional Committee of Chinese Nursing Association, a series of management measures were taken. The baseline and the second survey was conducted in July 2018 and July 2019 respectively. Implementation of informationized QTM in 2018 and 2019 was compared. Results In 2018, 1 972 hospitals participated in the survey, CSSDs in 1 633 (82.81%) of hospitals implemented QTM for centralized processing of sterile items; in 2019, 2 728 hospitals participated in the survey, CSSDs in 2 606 (95.53%) hospitals implemented QTM for centralized processing of sterile items. There was significant difference in the proportion of quality traceability methods used by the investigated hospitals in the past two years (χ²=43.339, P < 0.001), difference among different levels of hospitals was significant (all P < 0.001). Distribution of quality traceability function and management function in different levels of hospitals during two years was significantly different (all P < 0.001). Of the 919 hospitals that implemented informationized QTM, 572 (62.24%) hospitals all achieved traceability (all centralized processed items were included in informationized QTM), and 471 (82.34%) hospitals mainly used each sterilization package as the traceability granularity. Conclusion informationized QTM in domestic hospitals needs to be improved, rational selection of label technology, development of information system function and improvement of traceability granularity can further improve the quality and efficiency of CSSDs with the help of information development.