Objective To establish a risk assessment system for respiratory tract infection in health care workers (HCWs) in outpatient settings of medical institutions. Methods Brainstorming method and literature Meta-analysis method were used to identify risk points, risk points were classified and evaluated by scatter plot of risk, weight of risk points was calculated by analytic hierarchy process. Results The risk assessment system included four risk categories: "diagnosis and treatment process", "environment and layout", "personnel protection" and "emergency disposal", involving a total of 18 risk points. Conclusion The risk assessment system constructed in this study is helpful for the classification management for respiratory tract infection risk in HCWs in outpatient settings.