Research progress on virulence and drug resistance mechanism of hypervi-rulent Klebsiella pneumoniae
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Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

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    Abstract:

    Since the mid-1980s, incidence of hypervirulent Klebsiella pneumoniae (hvKp) has increased year by year, which has attracted global attention. hvKp is more pathogenic than classic Klebsiella pneumoniae (cKp), it can lead to invasive infection in healthy people, not only with high mortality (3%-31%), but also often accompanied by serious sequelae, such as blindness or neurological diseases. What is more worrying is that, in recent years, the emergence of hvKp strains resistant to the third generation cephalosporins, carbapenem antibiotics and colistin has brought great challenge to clinical treatment and management. Therefore, understanding virulence and drug resis-tance mechanism of hvKp is particularly important, this paper reviews the latest research progress of hvKp.

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蒋玉婷,张珂,刘唐娟,等.高毒力肺炎克雷伯菌毒力和耐药机制研究进展[J].中国感染控制杂志英文版,2021,(5):473-480. DOI:10.12138/j. issn.1671-9638.20217799.
Yu-ting JIANG, Ke ZHANG, Tang-juan LIU, et al. Research progress on virulence and drug resistance mechanism of hypervi-rulent Klebsiella pneumoniae[J]. Chin J Infect Control, 2021,(5):473-480. DOI:10.12138/j. issn.1671-9638.20217799.

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History
  • Received:July 16,2020
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  • Online: July 26,2021
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